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Colostrum is one of the most researched and studied substances in the world. A goverment site that post all the clinical trials from around the globe is pubmed.gov. From here you can do a search for colostrum and what ever issue is of concern to you. There are hundred of thousands of clinic studies below are just a few samples.

Anti-infective activity of anti-influenza antibodies from human colostrum

[Article in Russian]

Shvartsman IaS, Kontorovich EA, Agranovskaia EN, Grigoreva SK.

Antibodies against influenza virus of A, B serological types and PC-virus were detected in the colostrum collected after an epidemic. These antibodies belonged to the secretory IgA form. The secretory antibodies preparation made of colostrum, and its IgA fraction instilled intransally to mice and rats prevented the development of infection caused by 100/10 ID50/0.1 ml of the ,. The protective action of the antibodies of IgA class was due to its capacity to become fixed on the surface of the cells of the mucosal epithelium of the respiratory tract.

PMID: 419910 [PubMed - indexed for MEDLINE]

 

Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells

Biswas P, Vecchi A, Mantegani P, Mantelli B, Fortis C, Lazzarin A.

San Raffaele Scientific Institute, Milan, Italy, Lab. of Clinical Immunology/Clinic of Infectious Diseases. This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Human and bovine colostrum (BC) contain a remarkable amount of bioactive substances, including antibodies towards many common pathogens of the intestinal and respiratory tract as well as growth factors, vitamins, cytokines and other proteic, lipidic and glucidic factors. In this study we investigated whether BC had any immunomodulatory effect on human peripheral blood mononuclear cells (PBMC) from healthy donors. To this aim we focused on the production of IL-12 and IFN-gamma, cytokines involved in the Th1 polarization required for a successful immune response towards intracellular pathogens, such as bacteria and viruses. BC induced a dose-dependent production of IL-12 by CD14+ monocytes, but was unable to induce IFN-gamma production. However, BC differentially affected stimuli-induced IFN-gamma production: it enhanced IFN-gamma in response to weak antigenic stimulation and it inhibited IFN-gamma in response to strong antigenic stimulation. These effects were not dose-dependent. We also measured PBMC proliferation, which was substantially unaffected by BC. Our data suggest that the Th1-promoting activity of BC could contribute, together with the antibodies, to the protective effect of BC on the offspring. BC could also represent an inexpensive therapeutic tool in prevention and treatment of several human microbial infections, including influenza.

PMID: 18080681 [PubMed - indexed for MEDLINE]

 

Curr Protein Pept Sci. 2009 Aug;10(4):308-38.

Molecular and biotechnological advances in milk proteins in relation to human health

Kanwar JR, Kanwar RK, Sun X, Punj V, Matta H, Morley SM, Parratt A, Puri M,

Sehgal R.

Institute of Biotechnology (BioDeakin), Institute for Technology Research and Innovation,

Geelong Technology Precinct, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia. This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Milk and colostrum is a rich source of proteins/peptides which have crucial roles in both neonates and adults. Milk bioactive proteins and peptides are potential health-enhancing nutraceuticals for food. Many bioactive peptides/proteins may be used as nutraceuticals, for example, in the treatment of cancer, asthma, diarrhea, hypertension, thrombosis, dental diseases, as well as mineral malabsorption, and immunodeficiency.

The following components of milk are of particular interest in the recent years:

1) Lactoferrin [Lf] has antibacterial, antifungal, antiviral, antiparasite and antitumor activities and accelerates immunomodulatory properties. Lf is a potent inhibitor for several enveloped and naked viruses, such as rotavirus, enterovirus and adenovirus. Lf is resistant to tryptic digestion and breast-fed infants excrete high levels of faecal Lf, so that its effect on viruses replicating in the gastrointestinal tract is of great interest.

2) Casein has been protective in experimental bacteremia by eliciting myelopoiesis. Casein hydrolyzates were also protective in diabetic animals, reduced the tumor growth and diminished colicky symptoms in infants.

3) A Proline rich polypeptide [PRP] revealed variety of immunotropic functions, including promotion of T-cell activation and inhibition of autoimmune disorders such as multiple sclerosis.

4) alpha-Lactalbumin [LA] demonstrates antiviral, antitumor and anti-stress properties.

5) Lactoperoxidase shows antibacterial properties.

6) Lysozyme is effective in treatment of periodentitis and prevention of tooth decay.

Taken together, milk-derived proteins and peptides are bio-available and safe for the prevention and treatment of various disorders in humans and may play a complementary [natural agents] rather than a substitutional role to the toxic synthetic pharmacological drugs.

PMID: 19689355 [PubMed - in process

 

PREVENTION OF INFLUENZA EPISODES WITH COLOSTRUM COMPARED WITH VACCINATION IN HEALTHY HIGH-RISK CARDIOVASCULAR PATIENTS SUBJECT: THE EPIDEMIOLOGIC STUDY IN SAN VALENTINO Maria Rosaria Cesarone, MD, Gianni Belcaro, MD, PhD, Andrea Di Renzo, BA, Mark Dugall, PhD, Marisa Cacchio, MD, Irma Ruffini, MD, Luciano Pellegrini, MD, Gilberto Del Boccio, MD, Filiberto Fano, BA, Andrea Ledda, MD, Angelica Bottari, MD, Andrea Ricci, MD, Stefano Stuard, MD, and Giulia Vinciguerra, PhD From San Valentino-Spoltore Vascular Screening Project, Department of Biomedical Sciences, G D'anmmzio University, Chicti, Pescara, Italy The efficacy of a 2-month treatment with oral colostrum in the prevention of flu episodes compared with anti-influenza vaccination was evaluated. Groups included healthy subjects without prophylaxis and those receiving both vaccination and colostrum. After 3 months of follow up, the number of days with flu was 3 times higher in the non-colostrum subjects. The colostrum group had 13 episodes versus 14 in the colostrum + vaccination group, 41 in the group without prophylaxis, and 57 in non-treated Subjects. Part 2 of the study had a similar protocol with 65 very high-risk cardiovascular subjects, all of whom had prophylaxis. The incidence of complications and hospital admission was higher in the group that received only a vaccination compared with the colostrum groups. Colostrum both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective. Citation: Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Cesarone MR - Clin Appl Thromb Hemost - 01-APR-2007; 13(2): 130-6 MEDLINEŽ is the source for the citation and abstract of this record